Clinical and Epidemiological Manifestations of Ixodic Tick-Borne Borreliosis Foci in the Tomsk region

Relevance. According to official data, in 2020 Russia, Ixodic tick-borne borreliosis took the leading position prevalence and registration frequency among infections, which amounted 38.5% of all cases natural focal transmissible infections. In Tomsk region for many years, average long-term incidence exceeds Russian one by more than 3 times. Aim. Identify features clinical epidemiological manifestations tick borne foci region; identify priority areas carrying out problem-oriented research field ecology, epidemiology clinic infection region. Materials methods. The material study was data federal statistical observation form «Information on infectious parasitic morbidity» 2015-2020. materials 713 disease 125 thousand appeals medical organizations regarding bites, registered forms, were studied. As part annual monitoring a six-year period, 1200 specimens Ixodid ticks collected biotopes examined presence Borrelia DNA, depending their genus (Ixodes Dermacentor). DNA detection burgdorferi sensu lato complex (B. burgdorferi, B. garinii, afzelii) miyamotoi performed real-time PCR. Results. high number ixodid local (up 200.0 specimens/km at height season), as well failure comply with personal prevention measures, determines consistently rate referral population due bites. requests annually averages 20.8 thousand. result an using PCR tests taken from people who applied emergency centers, detected 40% samples; blood samples individuals affected bites positive 3.7% cases. period 2015-2019 spirochetes garinii afzelii most often found tissues ticks. Since 2020, species has been included list pathogenic borrelia be monitored – spontaneous (Ixodes) 3%. maximum values both patients ixodic density infections per 10,000 hectares (90-110 cases) are observed south (Asinovskyi, Kozhevnikovskyi, Krivosheinskyi, Tomskyi, Shegarskyi districts, city Tomsk). epidemic season laboratory-confirmed non-erythema 2.5 times higher diseases skin manifestations. Conclusion. large ixode mites biotopes, degree indicate active genotypic diversity borrelias relation vectors, analysis different etiological variants (mono- mixed infections), development algorithm differential diagnostic search model predicting outcomes process directions scientific